双歧杆菌如何助力肾脏健康？一文了解婴儿肾脏微生物组

仍要因如此，掺入含有粗双歧霉菌 C50 和嗜微大肠杆菌 065 以及益生元极低聚酱油或仅含有益生元的女婴糖浆保健食品也被主要用途协助纯洗手哺育的女婴或仍要从用药过渡到洗手哺育的女婴获得与用药女婴更为为相近的肠胃有机物一组。

早所产儿患坏死性肾脏腹腔炎的不太才会极高，因此才会也可以对其采用益生菌介入。在这多方面，欧洲各国耳鼻喉科胃肠病研习、肺病研习和营养素研习协才会会明确提出了一项建言（迹象等级较极低），即给予鼠李酱油牛奶霉菌 GG ATCC53103 或女婴双歧霉菌 Bb-02、三酸甘油酯双歧霉菌 Bb-12 和嗜微大肠杆菌 TH-4 的甲醇，以降极低早所产儿坏死性肾脏腹腔炎的发生率。

虽然致病反应在这些流程里的参与总体不一定都明确，但这些研究成果确实，不一定需要特定的益生菌有才会可以协助女婴们仅有身心健康的肠胃有机物一组，从而主要用途生命更早致病反应会的发展，并预防某些与生命末期肠胃有机物一组变动有关的性疾病。

参考文献：

1. Laursen MF. Gut microbiota development: influence of diet from infancy to toddlerhood. Ann Nutr Metab. 2021; 77(suppl 3):21-34. doi: 10.1159/000517912.

2. Stewart CJ, Ajami NJ, O’Brien JL, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature. 2018; 562:583-8. doi: 10.10138/s41586-018-0617-x.

3. Ma J, Li Z, Zhang W, et al. Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants. Sci Rep. 2020; 10(1):15792. doi: 10.1038/s41598-020-72635-x.

4. Bridgman SL, Azad MB, Field CJ, et al. Fecal short-chain fatty acid variations by breastfeeding status in infants at 4 months: differences in relative versus absolute concentrations. Front Nutr. 2017; 4:11. doi: 10.3389/fnut.2017.00011.

5. Rodríguez JM. The origin of human milk bacteria: is there a bacterial entero-mammary pathway during late pregnancy and lactation? Adv Nutr. 2014; 5(6):779-784. doi: 10.3945/an.114.007229.

6. de Weerth C, Aatsinki AK, Azad MB, et al. Human milk: from complex tailored nutrition to bioactive impact on child cognition and behior. Crit Rev Food Sci Nutr. 2022; 1-38. doi: 10.1080/10408398.2022.2053058.

7. Selma-Royo M, Calvo Lerma, J, Cortés-Macías E, et al. Human milk microbiome: from actual knowledge to future perspective. Semin Perinatol. 2021; 45(6):151450. doi: 10.1016/j.semperi.2021.151450.

8. Stuivenberg GA, Burton JP, Bron PA, et al. Why are Bifidobacteria important for infants? Microorganisms. 2022; 10(2):278. doi: 10.3390/microorganisms10020278.

9. Alessandri G, van Sinderen D, Ventura M. The genus bifidobacterium: from genomics to functionality of an important component of the mammalian gut microbiota. Comput Struct Biotechnol J. 2021; 19:1472-87. doi: 10.1016/j.csbj.2021.03.006.

10. Henrick BM, Rodriguez L, Lakshmikanth T, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021; 184(15):3884-98. doi: 10.1016/j.cell.2021.05.030.

11. Yang W, Tian L, Luo J, et al. Ongoing supplementation of probiotics to cesarean-born neonates during the first month of life may impact the gut microbial. Am J Perinatol. 2021; 38(11):1181-91. doi: 10.1055/s-0040-1710559.

12. Hurkala J, Lauterbach R, Radziszewska R, et al. Effect of a short-time probiotic supplementation on the abundance of the main constituents of the gut microbiota of term newborns delivered by cesarean section – a randomized, prospective, controlled clinical trial. Nutrients. 2020; 12(10):3128. doi: 10.3390/nu12103128.

13. Korpela K, Salonen A, Vepsäläinen O, et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome. 2018; 6(1):182. doi: 10.1186/s40168-018-0567-4.

14. Béghin L, Tims S, Roelofs M, et al. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants. Clin Nutr. 2021; 40(3):778-87. doi: 10.1016/j.clnu.2020.07.024.

15. Zhu B, Zheng S, Lin K, et al. Effects of infant formula supplemented with prebiotics and OPO on infancy fecal microbiota: a pilot randomized clinical trial. Front Cell Infect Microbiol. 2021; 11:650407. doi: 10.3389/fcimb.2021.650407.

16. van den Akker CHP, van Goudoever JB, Shamir R, et al. Probiotics and preterm infants: a position paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for pr. J Pediatr Gastroenterol Nutr. 2020; 70(5):664-80. doi: 10.1097/MPG.0000000000002655.

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笔记｜Andreu Prados

编译｜lxx